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Wwe 13 pal wii multi icon iso FREE. wwe 13 pal wii multi icon iso Games on Nintendo Wii. wwe 13 pal wii multi icon iso Free.Mesenchymal Stem Cell Therapy for Ankylosing Spondylitis: A Systematic Review and Network Meta-Analysis.
Traditional evidence-based medicine in medicine considers randomized controlled trials and systematic reviews as gold standards for determining the relative efficacy of interventions. The robust quality of evidence produced by these designs often limits the use of clinical practice guidelines. Network meta-analysis allows for the comparison of different interventions within the same evidence network. To provide evidence for the potential use of mesenchymal stem cells (MSCs) as a treatment for ankylosing spondylitis (AS) through a network meta-analysis. This review compares MSCs with other treatment modalities for the treatment of AS. A systematic review of randomized controlled trials and systematic reviews on MSCs in AS was conducted. Nine databases were searched from inception to May 2016. Based on the study selection criteria, nine MSC studies reporting on 462 patients were included. All patients were diagnosed with AS according to the New York criteria. Random-effect network meta-analyses were used to investigate the superiority of MSCs in improving AS disease activity and function. Because of the heterogeneity in the current AS trials, subgroup analyses were conducted to identify factors that could explain the heterogeneity. According to the primary outcomes, MSCs are ranked in the following order: MSCs may be more effective than infliximab for improving AS function and AS disease activity; MSCs may be superior to adalimumab, anti-tum
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