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Isobutyl-2-cyanoacrylate as an alternative to microfibrillar collagen in dermal wounds.
Dermal wounds are the most common injuries following surgery, and treatment is a key step to improve the outcome of these conditions. Collagen-based products are used in clinics to help primary healing of dermal wounds. This work assesses the effects of two new isolates of bioactive capsules (ISI-ISB) produced from the regrowth of natural green algae, Spongiadema guaycipanum, on dermal wound healing. Both ISI-ISB were evaluated for their ability to promote the development of dermal wounds in mice, and different groups of animals were treated with anticoagulant and/or microfibrillar collagen. Wound closure was performed 7, 14, and 21 days post-wounding and results were evaluated by wound area measurements, collagen density/pixel in histological sections and by the tensiometric method. The experimental groups that received a combination of anticoagulants and ISI-ISB had a significantly lower wound area at the last time point compared with the untreated control, reaching the best results when treated with ISI-ISB in combination with microfibrillar collagen. These data suggest that the combination of anti-coagulants and ISI-ISB is a promising agent to promote dermal wound healing in a timely manner.
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