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Atypical antipsychotics are widely prescribed to manage mood disorders and schizophrenia. However, recent studies suggest that their use may lead to diabetes and obesity, which are associated with increased risk of pancreatic cancer. We conducted a nested case-control study to assess the association between the use of atypical antipsychotics and the risk of pancreatic cancer. Cases were individuals with incident pancreatic cancer identified from the SEER Cancer Registry during 2001-2007. We matched them by race, sex, age and calendar year to 5 controls individually randomly selected from among cancer-free individuals who were identified from the same SEER Cancer Registry. Exposure was based on antipsychotic medication use in the 4 years preceding the index date for cases, and the corresponding years among the controls. Conditional logistic regression was used to estimate adjusted odds ratios (ORs) and 95% confidence intervals (CIs). A total of 516 cases and 2588 controls were included. After adjusting for potential confounders, a >5-fold increased risk of pancreatic cancer was observed among antipsychotic users compared with nonusers (adjusted OR, 5.91; 95% CI, 1.81-18.99). Specifically, users of atypical antipsychotics had a nonsignificant 4.35-fold increased risk of pancreatic cancer (95% CI, 0.84-23.09). There was little difference in the risk of pancreatic cancer for atypical antipsychotic use in the three subgroups defined by age, sex, and race/ethnicity. Atypical antipsychotic use was associated with a significant increased risk of pancreatic cancer. The association was not significant for atypical antipsychotic use but may have been obscured by the limited size of the subgroups analyzed.This invention relates to medical equipment for delivering fluids, such as insulin, to patients. More particularly, it relates to a fluid delivery system incorporating an improved combination of components and to a method of using the components to deliver fluid.
Numerous portable fluid delivery systems have been devised for administering fluids intravenously and subcutaneously to patients. Each fluid delivery system typically includes a disposable set of components, which are designed for a single use. The disposable set includes a
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