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To evaluate the feasibility, toxicity, and response rate of hepatic arterial infusion for metastatic breast cancer. From March 1990 through March 1993, 20 patients were treated with doxorubicin (60 mg/m2 as a bolus of lipiodol; 30 mg/m2 of doxorubicin) and cisplatin (100 mg/m2) infused for 4-6 hours through a hepatic artery catheter. Patients had progressive disease, multiple hepatic metastases, and/or major extrahepatic metastatic disease. The interval between beginning chemotherapy and insertion of the catheter ranged from 2 to 18 months. Catheter placement was facilitated with the use of a percutaneous transhepatic approach to access the hepatic artery. All patients had measurable hepatic metastatic disease, and 20 patients had evaluable disease. Five patients had stable disease for a median of 8.8 months (range, 7-18 months). Nine patients experienced toxicity, including fatigue, fever, and abdominal pain. Toxic reactions required a reduction in the intensity of treatment for one patient and treatment was withheld for a second patient. Hepatic arterial infusion of chemotherapy is well tolerated and has shown significant, but transient, antitumor activity in this group of patients.pone.0186598.ref066]\]. Also, in the present experiment, the glutamate–mediated excitatory and GABAergic inhibitory effects as well as the basal and ACh-mediated inhibitory effects were modulated by vehicle and TXA2 synthase inhibitor in the presence of 5-HT. Therefore, we further investigated the state of 5-HT system in the NTS under basal and ACh conditions. The NTS 5-HT system is a major source for the synthesis and release of ACh \[[@pone.0186598.ref011], [@pone.0186598.ref033], [@pone.0186598.ref034]\]. The release of 5-HT and ACh may be tightly coupled and correlated. The inhibition of 5-HT synthesis by tetrabenazine decreased the level of ACh released in the SFO of PPP,
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